Copper Peptide + Estriol Cream
For skin that has changed with time. Estriol, a copper peptide and vitamin C, compounded for you as one daily cream.
SELECT A PLAN
- Guided by a licensed provider
- Application and ramp guidance included
- Free shipping, discreet packaging
- Cancel anytime
Renews at $450 every 5 months unless you cancel. If your provider doesn't approve your protocol, our team processes a full refund.
Product details
- Estriol
- Copper Peptide (GHK-Cu)
- Vitamin C
Licensed Providers
503A/B Pharmacy Standard
HIPAA Compliant
No Appointment Needed
Cancel Anytime
OUR STANDARD
Medical-Grade Skincare
All of our products are made with nourishing, skin-loving ingredients that help support the integrity of your skin.
We don't hide behind vague "clean beauty" marketing. Our formulas are prescribed by licensed providers and made with clinically studied ingredients chosen to help repair, protect, and support your skin barrier. This is real medicine, designed for real results.
HOW TO USE
Copper Peptide + Estriol Cream
Nightly to start, a pea-sized amount on clean, dry skin. After a few weeks, once or twice a day as tolerated, with sunscreen every morning and clean hands after every application.
Copper Peptide (GHK-Cu)
Estriol
Vitamin C
The Results Speak for Themselves
- 61%at least 61% shallower wrinkles and smaller pores after six months of 0.3% estriol cream, in a study of 59 women in perimenopause.¹
- 74%greater improvement in skin texture with topical vitamin C in three months, versus a plain cream.²
- 60%less of the copper peptide in your body at 60 than at 20. This cream puts it back where it's studied for firmness and fine lines.³
- Cellular LongevityStrengthens moisture retention and skin resilience.
- Collagen SupportHelps maintain firmness and visible skin elasticity.
- Barrier RepairSupports healthier aging at the cellular level.
- Internal RegenerationPromotes renewal processes from within.
- Surface RenewalRefines texture and supports smoother-looking skin.
- Cellular LongevityStrengthens moisture retention and skin resilience.
- Collagen SupportHelps maintain firmness and visible skin elasticity.
- Barrier RepairSupports healthier aging at the cellular level.
- Internal RegenerationPromotes renewal processes from within.
- Surface RenewalRefines texture and supports smoother-looking skin.
FULL-SPECTRUM SKIN PROTOCOL
Better Together
Aging shows up across tone, texture and the hormonal shifts that change skin over time, and the Radiance System reaches all three. Tretinoin at night, the estriol cream daily, and a weekly capsule, prescribed together as one routine.
View the Radiance System
What to Expect
- Weeks 1 to 2Vitamin C often tingles a little on application at first. That fades, and the daily habit is what matters: cream at night, SPF in the morning.
- Weeks 3 to 6Brightness is usually the first thing people notice, along with skin that looks more rested and evenly hydrated.
- Weeks 8 to 12Tone evens gradually. Dullness gives way to a clearer, more even surface as the routine compounds.
- Month 3 and onThe vitamin C trial assessed skin at six months, and that is the horizon to plan for. Daily use, daily SPF, and the results keep building.
SAFETY, PLAINLY
SAFETY, PLAINLY
Common side effects
Mild stinging, tingling or redness on application, more likely on sensitive skin, usually settling. Rarely, an allergic reaction to an ingredient.
Sun and other actives
Vitamin C may increase sun sensitivity; daily SPF. It pairs with tretinoin in the same routine; your provider sets the order and the nights.
Who should not use this cream
Currently prescribed only for women. Not for you if you have a known allergy to any ingredient. Tell your provider if you are pregnant or nursing, and about any other prescription skincare you use.
When to contact your provider
Anytime through your account. Promptly for severe irritation, blistering, or signs of an allergic reaction.
How it works
What Happens After You Start
Your Assessment Goes to a Licensed Provider
A few minutes of questions about your health, history, and goals, no appointment required. The provider reviews your answers against what you've requested, and nothing is compounded or shipped until they approve.
Your Prescription Ships After Approval
Compounded for you by a licensed pharmacy, then shipped to your door with everything you need to start: your medication, supplies, and instructions for use.
Continuous Provider Care
Your prescription isn't a one-off purchase. At each check-in or renewal, your provider revisits what you're prescribed.
Who’s behind every order
Held to the Highest Standard
Prescribed by a licensed provider, fulfilled by a state-licensed 503A or 503B pharmacy, with documented ingredients, every time.
Provider
Licensed to prescribe in your state. Nothing is compounded or shipped without their approval.
Pharmacy
Compounded to your individual prescription by a 503A pharmacy, licensed and inspected by its state board of pharmacy.
Ingredients
Active ingredients with certificates of analysis for identity and purity.
COMMON QUESTIONS
COMMON QUESTIONS
RELATED
SOURCES
- Int J DermatolSix-month open-label study of 0.3% estriol cream in 59 perimenopausal women; no placebo group
- Arch Otolaryngol Head Neck SurgThree-month split-face trial of topical ascorbic acid against vehicle
- Int J Mol SciReview; GHK blood levels fall from about 200 to 80 ng/mL between ages 20 and 60
Results may vary and are not guaranteed. Compounded medications are customized to meet individual patient needs and are not reviewed by the FDA for safety, efficacy, or quality.
All product imagery is for representation only and does not represent the label you may receive from our licensed pharmacy partners. Your health information and medical history will be assessed by licensed physicians, who will decide if you are eligible for treatment and determine a treatment plan and medication if appropriate.
The information anywhere on this website does not constitute medical advice and should be used for informational purposes only and does not establish a patient/doctor relationship. Please make sure to discuss the risks and benefits of any treatment with your medical provider before beginning treatment.